Laboratory

An important part of our work is the laboratory where we carry out academic research projects. Our research laboratory is also involved in several of our clinical vaccine studies. Like the Vaccine Research Center, the laboratory is a part of the Faculty of Medicine and Health Technology of the Tampere University.

The laboratory is led by Vesna Blazevic, PhD

The research team has a strong and wide-ranging expertise in both traditional and current top-level methods in immunology, cell culture, molecular biology and biochemistry, i.a. multi-colour flow cytometry, PCR, cloning, protein production in cell cultures, and next-generation sequencing (NGS).

At the moment, the laboratory employs five researchers: PhD Maria Malm, PhD Suvi Heinimäki, PhD Kirsi Tamminen, M.D. Jukka Markkula and B.M. Oskari Pitkänen.

The main research topics include:

  • Developement of new generation subunit non-live vaccines.
  • Developing a vaccine against paediatric gastroenteritis as a combination vaccine based on the virus-like particles (VLP) of norovirus and the VP6-protein of rotavirus.

Specific expertise:

  • Vaccine antigen design
  • Vaccine production and specification at the laboratory scale
  • Vaccine adjuvants and novel vaccine delivery platforms
  • Vaccine immunogenicity/primary pharmacodynamics and proof-of-concept studies
  • Translation of knowledge from animal studies into clinical approaches
  • Vaccine immunogenicity in clinical trials
  • Norovirus epidemiology, genotype distribution and virus-induced immunity
  • Rotavirus epidemiology and genetic evolution
  • Rotavirus vaccine studies: real-life effectiveness
  • Epidemiology and pathogenicity of sapovirus and astrovirus

PhD theses in vaccine research

Maria Hemming-Harlo 28 May, 2014

Leena Huhti 1 April, 2015

Kirsi Tamminen 12 June, 2015

Suvi Lappalainen 6 November, 2015

Sirpa Räsänen 22 January, 2016

Minna Paloniemi 15 April, 2016